Isha Isatu Sesay (/ˈaɪʃə səˈseɪ/ ^ⓘ EYE-shə sə-SAY; born 6 January 1976) is a British journalist of Sierra Leonean descent. From 2005 to 2018, she worked as an anchor and correspondent for CNN International. She was originally based at CNN's world headquarters in Atlanta, Georgia, U.S. and now based in Los Angeles, California, where she hosted the news programs CNN Newsroom Live from Los Angeles. She was the presenter of the "360 Bulletin" on Anderson Cooper 360°. In 2012, Sesay joined HLN as a co-anchor for Evening Express. She left CNN in 2018 to support an AFrica girls' education project called W.E. Can Lead, write a book and pursue various other personal projects.

Born in London, England in 1976 to Temne parents from Sierra Leone, Sesay returned with them at the age of seven to their homeland. Raised in their Muslim faith, she lived in Sierra Leone for most of her childhood. She is one of three children, with an older sister and a younger brother. Isha's mother is Dr. Kadi Sesay, a former lecturer at Fourah Bay College. Dr. Sesay, in 1992, was appointed as an advisor to the government of Valentine Strasser. Isha's father worked as a legal advisor to the SLPMB (Sierra Leone Produce Marketing Board), a national regulatory institution; he died in 1988.

Sesay studied at the private Fourah Bay College School in Freetown. She also attended St. Joseph's Secondary School in Freetown. At the age of 16, in 1992 she moved to the UK for further study and college. After completing her A-levels, she was accepted into Trinity College, Cambridge, where she read English. She worked as a waitress in a bar while studying. She decided to become a television journalist, having previously aspired to become an actress. During her final year, she began writing to media groups seeking work.

After graduating, Sesay began her television career as a researcher for the BBC talk show Kilroy, initially as an unpaid intern. She later was hired as a full-time paid employee. In 1998, she moved to Glasgow to work for BBC Scotland, and, after a period behind the camera, got her first job as a TV announcer on BBC Choice. She went on to present a variety of programmes for the BBC, CNN and TWI, before joining Sky in March 2002.

At Sky, Sesay spent over three years as an anchor on Good Morning Sports Fans for Sky Sports News. She considers the high points of this period to be meeting former boxer Michael Watson, interviewing Ellen MacArthur, and travelling with members of the Arsenal football team following an exhibition match at Reebok Stadium in Manchester in support of Nwankwo Kanu's heart foundation. She later moved to ITN, where she anchored the ITV Morning News programme, and was also a newsreader on the breakfast programme GMTV.

In November 2005, Sesay became a news anchor and correspondent at CNN International, based at the network's global headquarters in Atlanta, Georgia, in the United States. She travelled to Nigeria in April 2007 to cover the presidential election, where she conducted one-on-one interviews with both outgoing president Olusegun Obasanjo, and the newly-elected president Umaru Yar'Adua. Later that year, she was in South Africa to cover the launch of the Global Elders.

In 2009, Sesay became the host of the first edition of the weekday news program International Desk.

In 2011, she swapped roles with Michael Holmes, and was assigned as the presenter of BackStory.