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Isometheptene
View on Wikipediafrom Wikipedia
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| Clinical data | |
|---|---|
| AHFS/Drugs.com | International Drug Names |
| MedlinePlus | a601064 |
| Routes of administration | Oral |
| ATC code | |
| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.007.236 |
| Chemical and physical data | |
| Formula | C9H19N |
| Molar mass | 141.258 g·mol−1 |
| 3D model (JSmol) | |
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Isometheptene (usually as isometheptene mucate) is a sympathomimetic amine sometimes used in the treatment of migraines and tension headaches due to its vasoconstricting properties; that is, it causes constriction (narrowing) of blood vessels (arteries and veins).[1][2] Along with paracetamol and dichloralphenazone, it is one of the constituents of Amidrine.
Chemistry
[edit]Isometheptene is a monounsaturated aliphatic secondary amine.
Mechanism of action
[edit]Isometheptene's vasoconstricting properties arise through activation of the sympathetic nervous system via epinephrine and norepinephrine. These compounds elicit smooth muscle activation leading to vasoconstriction by interacting with cell surface adrenergic receptors.[3]
See also
[edit]References
[edit]- ^ Diamond S, Medina JL (October 1975). "Isometheptene--a non-ergot drug in the treatment of migraine". Headache. 15 (3): 211–3. doi:10.1111/j.1526-4610.1975.hed1503211.x. PMID 1100566. S2CID 34768775.
- ^ Behan PO (December 1978). "Isometheptene compound in the treatment of vascular headache". The Practitioner. 221 (1326): 937–9. PMID 372936.
- ^ "Isometheptene". Drug Bank.