The prime minister of Israel (Hebrew: רֹאשׁ הַמֶּמְשָׁלָה, romanized: Rosh HaMemshala, lit. 'Head of the Government', Hebrew abbreviation: רה״מ‎; Arabic: رئيس الحكومة, romanized: Ra'īs al-Ḥukūma) is the head of government and chief executive of the State of Israel.

Israel is a parliamentary republic with a president as the head of state. The president's powers are largely ceremonial, while the prime minister holds the executive power. The official residence of the prime minister, Beit Aghion, is in Jerusalem. The current prime minister is Benjamin Netanyahu of Likud, the ninth person to hold the position (excluding caretakers).

Following an election, the president nominates a member of the Knesset to become prime minister after asking party leaders whom they support for the position. The first candidate the president nominates has 28 days to form a viable government that can command a majority in the Knesset. He then presents a government platform and must receive a vote of confidence from the Knesset to take office. In practice, the prime minister is usually the leader of the largest party in the governing coalition. Since it is all but impossible for one party to win a majority in the Knesset, all Israeli governments have been coalitions between two or more parties. Between 1996 and 2001, the prime minister was directly elected, separately from the Knesset.

The prime minister's position is greatly enhanced compared to his counterparts in other parliamentary republics because he is both de jure and de facto chief executive. This is because Basic Law: The Government explicitly vests executive power in the Government, of which the prime minister is the leader. In most other parliamentary republics, the president is at least nominal chief executive, while usually required by convention to act on the advice of the cabinet.

The office of Prime Minister came into existence on 14 May 1948, the date of the Declaration of the Establishment of the State of Israel, when the provisional government was created. David Ben-Gurion, leader of Mapai and head of the Jewish Agency, became Israel's first prime minister. The position became permanent on 8 March 1949, when the first government was formed. Ben-Gurion retained his role until late 1953, when he resigned to settle in the Kibbutz of Sde Boker. He was replaced by Moshe Sharett. However, Ben-Gurion returned in a little under two years to reclaim his position. He resigned for a second time in 1963, breaking away from Mapai to form Rafi. Levi Eshkol took over as head of Mapai and prime minister. He became the first prime minister to head the country under the banner of two parties when Mapai formed the Alignment with Ahdut HaAvoda in 1965. In 1968 he also became the only party leader to command an absolute majority in the Knesset, after Mapam and Rafi merged into the Alignment, giving it 63 seats in the 120-seat Knesset.

On 26 February 1969, Eshkol became the first prime minister to die in office. He was temporarily replaced by Yigal Allon, whose stint lasted less than a month, as the party persuaded Golda Meir to return to political life and become prime minister in March 1969. Meir was Israel's first woman prime minister, and the third in the world (after Sirimavo Bandaranaike and Indira Gandhi).

Meir resigned in 1974 after the Agranat Commission published its findings on the Yom Kippur War, even though it had absolved her of blame. Yitzhak Rabin took over, though he also resigned towards the end of the eighth Knesset's term following a series of scandals. Those included the suicide of Housing Minister Avraham Ofer after police began investigating allegations that he had used party funds illegally, and the affair involving Asher Yadlin (the governor-designate of the Bank of Israel), who was sentenced to five years in prison for having accepted bribes. Rabin's wife, Leah, was also found to have had an overseas bank account, which was illegal in Israel at the time.

Menachem Begin became the first right-wing prime minister when his Likud won the 1977 elections, and retained the post in the 1981 elections. He resigned in 1983 for health reasons, passing the reins of power to Yitzhak Shamir.