On 6 January 2012, a bomb exploded in the Al-Midan district of Damascus, Syria. According to the Syrian government, a suicide bomber attacked buses carrying riot police shortly before an anti-government protest was to begin. It said that 26 people were killed and over 60 were injured. Most of the victims were civilians, though the Syrian government showed footage of what it claimed to be the funeral of 11 police officers killed in the attack.

It was the second such bombing since an uprising against the government began in early 2011. Two weeks earlier, a double car bombing in Damascus had killed 44 people. The government blamed that attack and the 6 January attack on al Qaeda. However, the Syrian opposition accused the government of staging the attacks to justify its crackdown on the uprising. Later, the newly formed Al-Nusra Front to Protect the Levant claimed responsibility in a video.

The attack occurred as Arab League monitors were in the country to see if Syria was abiding by Arab League demands that were said to have sought an end to the violence. Two weeks earlier, a double car bombing in Damascus had killed 44 people. The government blamed that attack on Islamist militants.

Most of the initial information about the attack comes from the Syrian government and state media. It reported that, at about 10:55, a suicide bomber detonated an explosive belt beside three buses carrying riot police. A police officer said that he had seen a man carrying a black bag walk toward a bus and then detonate the explosives. The buses were parked outside a police station that was near a primary school and a mosque. The bomb detonated at a traffic light under a concrete flyover, shattering windows and destroying several police cars. According to Syrian state media, it was estimated that the bomb was 10 kilograms of high explosive.

Syrian state news agency SANA reported that 26 were killed (including 15 who could not be identified) and 63 were hurt. It also said that most of the victims were civilians but that there were security personnel among the dead. Remains, allegedly those of the bomber, were left at the scene for several hours before being taken away for DNA tests. These and other body parts were repeatedly displayed for journalists who were driven to the scene by the Ministry of Information. State-owned television showed a damaged bus with blood and police helmets on the seats. Interior Minister Mohammed Shaar said that the bomber "detonated himself with the aim of killing the largest number of people."

Hundreds of government loyalists later arrived at the scene, some of whom were waving flags and chanting in support of Syrian president Bashar al-Assad. According to The New York Times, people living in the neighborhood reported that about an hour after the bombing, security forces and armed loyalists went on "a rampage, shooting randomly and beating and arresting people in the streets".

Despite the bombing, anti-government protests went ahead in Damascus and elsewhere. The anti-government Local Coordinating Committees said 14 protesters were killed in the suburbs of Damascus later that day. It also reported that nine protesters had been killed in Hama, eight were killed in Homs, three were killed in Idlib and one was killed in Deraa. SANA also reported that an oil pipeline between Hama and Idlib had been blown up by a "terrorist group."

The Interior Minister described the modus operandi and "intention to cause mass casualties" as having the "fingerprints of al-Qaida." Syria's interior ministry said the government would "strike back with an iron fist" to what it called "terrorist escalation".