Jean Tatlock grew up in a highly intellectual home. Her father's profession as a professor of Medieval Literature brought her in contact with academic society. Her mother was a writer and editor, and she likely participated in some of her work. The family moved across several college towns depending on her father's research.

During her time at Vassar and Stanford, Jean would have cultivated friendships and sought guidance from mentors. These relationships likely provided her with intellectual stimulation, emotional support, and opportunities for personal growth. Unfortunately, specifics about these relationships are not publicly known to any great extent. Further research may reveal more about the people who played a significant role in her life.

Based on accounts from those who knew her, Jean was described as intelligent, vibrant, and deeply compassionate. Her involvement in social causes and her dedication to the field of medicine would have undoubtedly made a lasting impression on the people around her. This social circle consisted of people in the Communist Party, fellow students, and colleagues.