Jessica Raine (born Jessica Lloyd; 1981/1982) is an English actress. She rose to prominence as Nurse Jennifer Lee in Call the Midwife (2012–2014) and is also well known as Verity Lambert in An Adventure in Space and Time (2013).

Raine portrayed Catherine Parr in Becoming Elizabeth and has played the lead role in The Devil's Hour since 2022. She has also had roles in stage and radio plays.

Raine was born Jessica Lloyd in Eardisley, Herefordshire, where she was raised on a farm. She is the younger of two daughters of farmer Allan Lloyd (descended from the Lloyd family of Baynham Hall, who were well known for generations as bonesetters alongside their farming activities), and his wife Sue.

Raine was educated in Kington, Herefordshire, and wanted to be an actress from the age of 13, as her father starred in amateur dramatics with the Eardisley Little Theatre. In sixth form she studied theatre at A-Level, and a BTEC in photography at Hereford College of Arts.

Raine studied drama and cultural studies at the University of the West of England, Bristol. After graduating, she was turned down by every drama school she applied to, so went to Thailand and taught English as a second language.

Returning home after a year, she applied to the Royal Academy of Dramatic Art a second time and was accepted. Moving to London in anticipation of starting her course, she worked part-time as a waitress and for BT Group.

After graduating in 2008, Raine began a successful stage career, initially cast as Lesley Sharp's goth daughter in Simon Stephens's Harper Regan. She played Tamsin Greig's 16-year-old daughter in David Hare's Gethsemane.

Raine played at the National Theatre in Mike Bartlett's Earthquakes in London as teenage wild-child Jasmine; and then as a secretary in the revival of Clifford Odets's Rocket to the Moon. She also appeared in Ghosts and Punk Rock, for which she won the Manchester Evening News Award for Best Supporting Actress.