Joseph Michael DeLamielleure (/dəˌlɑːməˈlɔːr/ də-LAH-mə-LOR; born March 16, 1951) is an American former professional football player who was a guard in the National Football League (NFL). He was an All-American playing college football for the Michigan State Spartans. He was selected by the Buffalo Bills in the first round of the 1973 NFL draft. He won All-Rookie Honors, after finding out a physical condition with his irregular heartbeat was not serious. In 1973 the Buffalo Bills rushing offense led the NFL in yards, yards per carry, as well as rushing touchdowns. He is also one of the first living NFL players to be tested and diagnosed with CTE (Chronic Traumatic Encephalopathy).

DeLamielleure was perhaps the central figure in the "Electric Company," the Bills' offensive line that paved the way for O. J. Simpson to rush for 2,003 yards in 1973, the first player ever to break that barrier, and the only player ever to do so in a 14-game schedule.

The league-leading rushing yardage mark of 3,088 yards is still the 14-game record. Only the 1978 New England Patriots have bettered that mark and did it in 16 games. Individually, Simpson led the NFL in all four major rushing categories. Joe also had the longest run in the NFL. The 2,003 yards Simpson rushed for is still the 14 game record (Eric Dickerson, Barry Sanders, Terrell Davis, Jamal Lewis, Chris Johnson, Adrian Peterson and Derrick Henry achieved their marks in 16 games). DeLamielleure was also on the kickoff return team that blocked for Wallace Francis, who led NFL with two return touchdowns. DeLamielleure played on the wedge of the kickoff return team his entire career in Buffalo.

The following year, 1974, the Bills improved to 9–5 and made the playoffs. DeLamielleure was voted second-team All-Pro. In 1975 the Bills displayed one of the most potent offenses of the decade. They led the NFL in eleven categories, including total offense, rushing, rushing average, points, touchdowns and touchdown passes en route to an 8–6 record. The offensive line also allowed the fewest sacks in AFC. Simpson, behind the "Electric Company" achieved his second "quadruple crown" in three years and also had the longest run in NFL. Individually, DeLamielleure was named First-team All-Pro.

DeLamielleure was named an All-Pro six times and was named to the Pro Bowl six times. In 1975, DeLamielleure was named by the NFLPA as Offensive Lineman of the Year. In 1973, DeLamielleure was Co-Offensive Linemen of the Year as awarded by the 1000 Yard Rusher Club, Columbus, Ohio. In 1977, DeLamielleure received the Forrest Gregg Award as the NFL's Top Offensive Lineman for that season.

In 1980, DeLamielleure was traded to the Cleveland Browns where he blocked for his 2nd NFL MVP, Brian Sipe. DeLamielleure became the first player ever to block for a 2,000-yard rusher and a 4,000-yard passer. Of those who have done it since, (Jackie Slater, Doug Smith, Irv Pankey, Kevin Glover, and Tom Nalen) only DeLamielleure's duo were NFL MVPs and the passer (Sipe) also won the NFL passing crown. Also, the 1980 Browns offensive line led NFL in allowing the lowest sacks percentage and blocked for a 1,000-yard runner (Mike Pruitt). During his five years with Cleveland, he played every game. In 1979, DeLamielleure was named to the NFL's All-Decade Team. He played his final year in the NFL, 1985, back with the Buffalo Bills.

In 1992, DeLamielleure had a short stint with the Charlotte Rage of the Arena Football League.

DeLamielleure was named to the Pro Football Hall of Fame in 2003 and was inducted to the East-West Shrine Game Hall of Fame in 2007.