Johannesburg East Commando was a light infantry regiment of the South African Army. It formed part of the South African Army Infantry Formation as well as the South African Territorial Reserve.

The Johannesburg East Defence Association was raised on 4 November 1924 under Government Gazette 24/1064 with its headquarters in Johan Rissik School in Troyeville.

By 1950 the association was renamed as the Johannesburg East Commando.

The unit resorted under the command of the SADF's Group 18.

During this era, the unit was mainly engaged in area force protection, search and cordons as well as other assistance to the local police.

As an urban unit, this commando was also tasked with protecting strategic facilities as well as quelling township riots especially during the State of Emergency in the 1980s.

In 1979 however the unit was renamed the Johannesburg South Commando and by 1983, the unit finally renamed again as the Johannesburg South Regiment.

The regiment developed into an urban counter insurgency unit, but was also involved in border duty.