Jonathan Mostow (born November 28, 1961) is an American film director, screenwriter, and producer. He has directed films such as Breakdown (1997), U-571 (2000), Terminator 3: Rise of the Machines (2003), and Surrogates (2009).

Mostow was born in Woodbridge, Connecticut. His father George Daniel Mostow was a mathematician, and his mother is a social worker. He graduated from Harvard University. He also trained at the American Repertory Company and the Lee Strasberg Institute. He grew up in a Conservative Jewish household.

In 1989, Mostow directed a direct-to-video horror comedy, Beverly Hills Bodysnatchers.

Mostow was originally attached to direct The Game (1997), with Kyle MacLachlan and Bridget Fonda for the lead roles. However, he ended up being an executive producer after David Fincher came on to direct. In 1997, he directed Breakdown, a thriller film starring Kurt Russell. Around the same time, he signed a deal with Universal Pictures. Both Mostow and Lieberman received a TV deal, via his Mostow/Lieberman Productions company to Studios USA.

In 2000, Mostow directed a World War II-era submarine film, U-571. He assembled a cast including Matthew McConaughey, Bill Paxton, Harvey Keitel, TC Carson, and Jon Bon Jovi. The film topped the U.S. box office chart.

In 2003, Mostow directed the third installment of the Terminator film series, Terminator 3: Rise of the Machines, which starred Arnold Schwarzenegger.

Mostow co-wrote a comic book series, The Megas, with John Harrison. Illustrated by Peter Rubin, it was published on Virgin Comics in 2008.

Mostow returned to direct another film, Surrogates, in 2009. Based on the comic book series, it starred Bruce Willis.