Joseph VI Audo (or Audu or Oddo) (1790–1878) was the Patriarch of the Chaldean Catholic Church from 1847 to 1878.

Joseph Audo was born in Alqosh in 1790 and in 1814 he became a monk of the monastery of Rabban Hormizd. He was ordained priest in 1818 and consecrated bishop of Mosul on the March 25, 1825, by the patriarchal administrator Augustine Hindi in Amid. From 1830 to 1847 he served as metropolitan bishop of Amadiya.

In the early 19th century there was not yet a formal union between the two patriarchal lines that professed to be in communion with the Holy See. The ancient monastery of Rabban Hormizd, that for many centuries was the see of the Mama patriarchal family supported by most of the East Syrian Christians, in 1808 recognized as its own patriarch Mar Augustine Hindi, the leader of a patriarchal line started by Mar Joseph I in 1681 in union with Rome. This was fiercely opposed by the last descendant of the Mama family, Yohannan Hormizd, also in communion with Rome. Joseph Audo was a partisan of Mar Augustine Hindi and thus became an active opponent of Yohannan Hormizd: the strong conflict came to an end only through the direct intervention of two apostolic delegates sent by Rome in 1828–1829.

In 1832, he was stripped and insulted by Kurdish troops of Mir Muhammad during a massacre at the Monastery, although he eventually persuaded them to end the Attack.

After the death of Augustine Hindi the Chaldean Church was finally united under the aged Yohannan Hormizd in 1830, even if he, and his successor Nicholas I Zayʿa, had to deal with the internal opposition of several bishops led by Audo that lasted up to the resignation of patriarch Nicholas Zaya in 1846.^{[citation needed]}

Joseph Audo was elected Patriarch of the Chaldean Church on July 28, 1847, and confirmed by Pope Pius IX on September 11, 1848. He is also remembered as Joseph VI, considering Mar Augustine Hindi to have the name of Joseph V.

Joseph showed himself to be as energetic and combative a patriarch as he had been a bishop. During his reign he took measures to improve the calibre of the Chaldean clergy and to strengthen the episcopate and the monastic order, and mounted a successful campaign to strengthen the spread of the Catholic faith into the Nestorian districts. A sincere Catholic, who had been brought to the Catholic faith after reading Joseph II's Book of the Pure Mirror, he clashed on a number of occasions with the Vatican on questions of jurisdiction.

Audo laid the foundations, with help from the Vatican, for the Chaldean Church to grow and flourish remarkably in the last decades before the First World War. From his early days as bishop of ʿAmadiya, competing with the Nestorian church for the allegiance of the villages of the Sapna valley, he had appreciated the crucial role an educated clergy could play both in consolidating the Catholic faith where it already existed and in bringing it to new hearers. Hitherto many of the Chaldean Church's bishops had been educated at the College of the Propaganda at Rome, and its priests had picked up what education they could from their bishops. Audo worked to reduce the Chaldean Church's dependence on Rome, and to ensure that it was able to train and educate its own clergy.