KTUU-TV (channel 2) is a television station in Anchorage, Alaska, United States, affiliated with NBC and CBS. It is owned by Gray Media alongside MyNetworkTV affiliate KAUU (channel 5). The two stations share studios on East 40th Avenue in midtown Anchorage; KTUU-TV's transmitter is located in Knik, Alaska.

Some of KTUU-TV's programming is broadcast to rural communities via low-power translators through the Alaska Rural Communications Service (ARCS).

The construction permit for channel 2 in Anchorage was issued on July 29, 1953, to Keith Kiggins and Richard R. Rollins. The permit took the call sign KFIA ("First in Anchorage") and then began construction, with an antenna being placed atop the Westward Hotel at Third Avenue and F Street. The same day the FCC granted a construction permit for channel 2, it also greenlit Anchorage's channel 11, KTVA, sparking a race to be the first broadcast television station in the territory (statehood for Alaska would come in 1959).

It appeared that KFIA was ahead when it announced it would broadcast its first test pattern on October 15, as KTVA was unpacking its equipment. However, it failed to put out a picture that night. Two days later, on the October 17, the first television test pattern in Alaska was broadcast, but the station missed its announced November 1 start date. Picture quality control equipment was late getting to Anchorage, pushing back the start date twice. It was only a month and a half later that KFIA made it on the air, on December 14, but in that time, it had lost its claim to be first in Anchorage with programming, as KTVA had signed on December 11. Both stations had also been beat by a cable system in Ketchikan to be the first source of television programming anywhere in the territory. When the station did get on the air, it did so "quietly and without fanfare", in the words of its general manager.

Midnight Sun Broadcasting (The Lathrop Company), owned by Alvin Oscar "Al" Bramstedt Sr. bought the station in 1954; the station's call letters were changed to KENI-TV in 1955; that year, it moved into the Fourth Avenue Theatre, also known as the Lathrop Building, downtown. Lathrop sold KENI-AM-TV plus its other radio and TV stations—KTKN in Ketchikan, KFAR-AM-TV in Fairbanks, and KINY-AM-TV in Juneau—to All-Alaska Broadcasting Company, which later became Midnight Sun Broadcasters in 1960.

On September 19, 1966, channel 2 became the first station in Alaska to transmit in color when it aired the premiere episode of the ABC sitcom That Girl (entitled "Don't Just Do Something, Stand There!"). The station had joint primary affiliation with NBC and ABC (with KTVA picking up some of the slack) until October 1, 1967, when it switched to ABC primary and NBC secondary, primarily because ABC had more programs on film. Channel 2 became a full-time ABC affiliate in 1970 when KHAR (channel 13, now KYUR) took the NBC affiliation. The two stations switched networks in October 1971, at which time KHAR became KIMO. Channel 2 also carried a few PBS programs (particularly The Electric Company) until KAKM signed on in 1975. Until KTVF in Fairbanks switched networks from CBS to NBC in April 1996, KTUU was the only full-time NBC affiliate in Alaska, clearing every network program. On June 3, 1981, Midnight Sun Broadcasters sold the station to Zaser and Longston of Bellevue, Washington, who changed the call letters to the current KTUU-TV the next week on June 10 in conjunction with the sale.

In August 2010, KTUU became the third Schurz-owned television station (after KWCH-DT and KSCW-DT in Wichita, Kansas, and WDBJ in Roanoke, Virginia) to relaunch its website through a new partnership with the Tribune Company's Tribune Interactive division. Previously, the Web address was operated by the local media division of World Now. The other Schurz television station websites, which were operated by Broadcast Interactive Media, also followed after their CMS contract with BIM ran out.

On November 9, 2013, KTUU-TV was dropped by GCI in 22 rural communities, after the two sides were unable to come to a new retransmission agreement, though GCI still carries some KTUU and NBC programming in some of these areas through the Alaska Rural Communications Service. The dispute did not involve areas (including Anchorage) where GCI carries KTUU through must-carry. The move followed the sale of rival KTVA to a subsidiary of GCI a week earlier, which KTUU had opposed over concerns that this move could be made. KTUU's channel slot on most of the affected systems was filled by Starz Kids & Family. Despite this dispute, KTUU extended its newscast carriage agreement with KATH-LD in Juneau and KSCT-LP in Sitka (which were also acquired by GCI at the same time it acquired KTVA) through November 22; that agreement was subsequently extended through December 6 as negotiations continued toward a long-term deal, but talks ultimately broke down, and by December 7 KATH/KSCT no longer aired KTUU programming. A deal between GCI and KTUU was finally reached on February 6, 2014; this allowed the station to return to GCI's rural systems (as well as separately-owned cable systems that receive KTUU through GCI) in time for NBC's broadcast of the 2014 Winter Olympics, as well as the eventual restoration of KTUU's newscasts to KATH/KSCT.