Karl Wendell Wilson (born September 10, 1964) is an American former professional football player who was a defensive lineman in the National Football League (NFL) for eight different teams. He was selected by the San Diego Chargers in the third round of the 1987 NFL draft. He played college football for the LSU Tigers.

With Dallas Cowboys left tackle Erik Williams, Wilson appeared on the cover of the video game Madden NFL '95, albeit with his shirt number changed to the unused number 70.