Karolina Šprem Baghdatis (born 25 October 1984) is a former professional tennis player from Croatia. She won eleven titles (ten singles), all at the ITF level. Her highest ranking is world No. 17, achieved in October 2004.

Karolina was born to Gabro and Božena Šprem in Varaždin, SFRY. She was introduced to tennis by her father at nine years of age. She turned professional in July 2001.

Šprem represented Croatia at the 2004 Summer Olympics held in Athens where she reached the third round in singles and the second round in doubles (with Jelena Kostanić).

On 14 July 2012, Šprem married ATP player Marcos Baghdatis at Trakošćan Castle in Croatia. At Wimbledon, as a spectator for Baghdatis' match on centre court against Andy Murray, Šprem confirmed that she and Baghdatis were expecting their first child. Karolina gave birth to a girl, named Zahara, on 20 October 2012.

Šprem displayed stunning results at the beginning of the 2003 season. Playing on the ITF Circuit, she had a record 29-match winning streak from January to March, which earned her four titles at Grenoble, Southampton, Redbridge and Castellón.

Later in the year, she went on to reach two WTA Tour-level finals in Strasbourg and Vienna. She also reached the semifinals of the WTA Tour event in Helsinki, and won the ITF event in Poitiers.

Šprem's career highlight came 2004 at Wimbledon, where she was a quarterfinalist. She defeated the then-two-time champion, four-time finalist and world No. 8, Venus Williams, en route. Her run was ended by Lindsay Davenport. The umpire of her match against Venus had awarded her an extra point in the second set tiebreak by mistake.

After Wimbledon, Karolina struggled to find her good form she had, losing early in many tournaments. She began training with Borna Bikić.