Kazuo Misaki (Japanese: 三崎和雄, born April 25, 1976) is a retired Japanese professional mixed martial artist. A professional competitor from 2001 until 2013, he was the 2006 PRIDE Welterweight (183 lbs) Grand Prix Champion, and also competed in Sengoku, Pancrase, DEEP, and Strikeforce. His 2010 bout with Jorge Santiago for the Sengoku Middleweight Championship was InsideMMA's "Fight of the Year."

Misaki started training judo in middle school. He later added kickboxing training in the Katori Dojo, and was finally introduced to mixed martial arts by Sanae Kikuta as part of his Grabaka team.

En route to the 2006 PRIDE Welterweight Grand Prix finals he defeated Phil Baroni and Dan Henderson in a non-title bout. Misaki was eliminated in the semifinals by Paulo Filho, but Filho injured his knee during the contest and was unable to continue to the finals. Misaki was named as his replacement and defeated Denis Kang by split decision.

His last fight in PRIDE was a unanimous decision loss to Frank Trigg at PRIDE 33 on February 24, 2007.

At the Yarennoka event on New Year's Eve 2007, he fought Yoshihiro Akiyama. The original result of the match was a knockout victory for Misaki, but Akiyama protested the finish. The knockout kick came as Akiyama attempted to get back to his feet after being knocked down by Misaki. Akiyama contested that one or more of his hands were on the mat at the time of the kick, which would make the kick illegal under Yarennoka! rules. After reviewing video of the knockout, the Yarennoka executive committee agreed; the official result was then changed to "no contest."

He went on to fight in World Victory Road's inaugural event "Sengoku", on March 5, 2008, where he defeated Siyar Bahadurzada. and won by guillotine choke at 2:02 of the second round.

His next fight was at Sengoku 3 on June 8, 2008, where he beat Logan Clark by unanimous decision.

He then signed with Strikeforce in 2008, where he was scheduled to fight Joe Riggs but was forced to pull out due to injury.