Russell starred in the title role of Felicity Porter in the WB series Felicity, earning her a Golden Globe Award.

She appeared in the film We Were Soldiers, a notable role in her film career.

Russell starred in the film The Upside of Anger, showcasing her versatility as an actress.

She played the role of Elizabeth Jennings in the spy thriller series The Americans, opposite Matthew Rhys.

Russell starred as Ambassador Kate Wyler in the political drama series The Diplomat.