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Kinase insert domain receptor

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Kinase insert domain receptor

Kinase insert domain receptor (KDR, a type IV receptor tyrosine kinase) also known as vascular endothelial growth factor receptor 2 (VEGFR-2) is a VEGF receptor. KDR is the human gene encoding it. KDR has also been designated as CD309 (cluster of differentiation 309). KDR is also known as Flk1 (Fetal Liver Kinase 1).

The Q472H germline KDR genetic variant affects VEGFR-2 phosphorylation and has been found to associate with microvessel density in NSCLC.

Kinase insert domain receptor has been shown to interact with SHC2, Annexin A5 and SHC1.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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protein-coding gene in the species Homo sapiens
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