Kitikmeot Region (/ˈkɪtəkmjuːt/; Inuktitut: ᕿᑎᕐᒥᐅᑦ, romanized: Qitirmiut ^{[pronunciation?]}) is an administrative region of Nunavut, Canada. It consists of the southern and eastern parts of Victoria Island with the adjacent part of the mainland as far as the Boothia Peninsula, together with King William Island and the southern portion of Prince of Wales Island. The regional centre is Cambridge Bay (population 1,760).

Before 1999, Kitikmeot Region existed under slightly different boundaries as Kitikmeot Region, Northwest Territories.

Access to the territorial capital of Iqaluit is difficult and expensive as there are no direct flights from Kitikmeot Region communities to Iqaluit. For example, Iqaluit is approximately 1,069 km (664 mi) from Kugaaruk, the closest Kitikmeot community. A one-way flight to the capital costs between $3,000 and $4,000 (as of April 2025) and involves flying to, along with an overnight stay in, Yellowknife, Northwest Territories, approximately 1,310 km (810 mi) southwest of Kugaaruk—in total, a trip of about 3,627 km (2,254 mi).

As is the case for the rest of Nunavut, there is no road access to the region and all places are fly-in. All five hamlets have certified airports: Cambridge Bay Airport, Gjoa Haven Airport, Kugaaruk Airport, Kugluktuk Airport and Taloyoak Airport, with scheduled flights by Canadian North.

There are also four registered aerodromes in the region. Cambridge Bay Water Aerodrome is a floatplane base open in the summer only. George Lake Aerodrome, an ice runway is only open from January to April, and serves the Back River Gold Project. Goose Lake Aerodrome also serves the Back River Gold Project and has both ice and gravel runways. Hope Bay Aerodrome serves the Hope Bay mine site and is a gravel runway. The former Doris Lake Aerodrome, was a 7,894 ft (2,406 m) ice runway, and was the longest in the region, it served the Doris Lake mine.

The Kitikmeot Region has a harsh subarctic climate (Köppen climate classification Dfc) and a tundra climate (Dfc) with long, very cold winters and short, cool summers.

The region is home to the only two communities in Nunavut that voted "no" in the 1982 division plebiscite: Cambridge Bay and Kugluktuk.

The region has four electoral districts;