Knittlingen (German pronunciation: [ˈknɪtlɪŋən] ^ⓘ) is a town in the Enz district in Baden-Württemberg in southern Germany.

It lies at the eastern edge of the Kraichgau in the centre of a rectangle that is formed by Heidelberg, Karlsruhe, Heilbronn, and Stuttgart.

The centre of Knittlingen consists of many old half-timbered houses.

Neighbouring towns and municipalities (clockwise): Sternenfels, Maulbronn, Ölbronn-Dürrn, (all Enz (district)), Bretten, and Oberderdingen, (both Karlsruhe (district)).

The motorways A5 (Bruchsal or Karlsruhe-Exit), A6 (Eppingen-Exit) and A8 Pforzheim-Exit are reachable within approximately 30 minutes.

Knittlingen-Kleinvillars station is located on the Württemberg Western Railway and is served by Karlsruhe Stadtbahn S 9 services to Karlsruhe, Bruchsal and Mühlacker.

The nearest airport is part of the Baden Airpark (officially Flughafen Karlsruhe/Baden-Baden) about 70 km southwest of Knittlingen, with regular connections to airports in Germany and Europe in general. Frankfurt International Airport can be reach in about an hour and a half by car, whereas Stuttgart Airport can be reached in about one hour.

Knittlingen was founded during the Frankish period. Records from the year 843 refer to it by the name "Cnudelingen." It was a possession of various religious and secular territories, including the Margraviate of Baden, until it finally came into the possession of Maulbronn Abbey, which held it from that time forward.