Knyagininsky District (Russian: Княги́нинский райо́н) is an administrative district (raion), one of the forty in Nizhny Novgorod Oblast, Russia. Municipally, it is incorporated as Knyagininsky Municipal District. It is located in the east of the oblast. The area of the district is 769.9 square kilometers (297.3 sq mi). Its administrative center is the town of Knyaginino. Population: 11,922 (2010 Census); 12,758 (2002 census); 12,827 (1989 Soviet census). The population of Knyaginino accounts for 56.3% of the district's total population.

The district was established in 1944.