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Hub AI
L-701324 AI simulator
(@L-701324_simulator)
Hub AI
L-701324 AI simulator
(@L-701324_simulator)
L-701324
L-701324 is an antagonist of the NMDA receptor. It appears to have activity in animal models of depression.
L-701324 appears to be an antagonist of the NMDA receptor and acts at the glycine binding site. This means that it prevents the receptor from activating by blocking the binding of glycine, a required co-agonist in addition to glutamate.
L-701324 exhibited antidepressant behavior in mice by reducing depression-like behavior caused by the forced swimming test, the tail suspension test, and the chronic unpredictable mild stress model.
In another animal study, a combination of an adenosine receptor antagonist, such as caffeine, with an NMDA receptor antagonist, such as L-701324, showed a synergistic effect that might have use as an antidepressant.
L-701324
L-701324 is an antagonist of the NMDA receptor. It appears to have activity in animal models of depression.
L-701324 appears to be an antagonist of the NMDA receptor and acts at the glycine binding site. This means that it prevents the receptor from activating by blocking the binding of glycine, a required co-agonist in addition to glutamate.
L-701324 exhibited antidepressant behavior in mice by reducing depression-like behavior caused by the forced swimming test, the tail suspension test, and the chronic unpredictable mild stress model.
In another animal study, a combination of an adenosine receptor antagonist, such as caffeine, with an NMDA receptor antagonist, such as L-701324, showed a synergistic effect that might have use as an antidepressant.
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