LISREL (linear structural relations) is a proprietary statistical software package used in structural equation modeling (SEM) for manifest and latent variables.

LISREL was developed in the 1970s by Karl Jöreskog, then a scientist at Educational Testing Service in Princeton, New Jersey, and Dag Sörbom, later both professors of Uppsala University in Sweden.

LISREL is mainly syntax-based, although recent versions have featured a graphical user interface (GUI).

In early 2020, SSI was acquired by the Vector Psychometric Group, a US-based software and consulting company.