LPAR2

LPAR2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4P0C
Identifiers
Aliases	LPAR2, EDG-4, EDG4, LPA-2, LPA2, lysophosphatidic acid receptor 2
External IDs	OMIM: 605110; MGI: 1858422; HomoloGene: 3465; GeneCards: LPAR2; OMA:LPAR2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	19,628,930 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	70,283,752 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; granulocyte; ; blood; ; right testis; ; spleen; ; left testis; ; monocyte; ; mucosa of transverse colon; ; right lung;
	Top expressed in
	granulocyte; ; yolk sac; ; epiblast; ; tail of embryo; ; otic vesicle; ; genital tubercle; ; ventricular zone; ; ganglion of vagus nerve; ; primitive streak; ; placenta;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	lipid binding; protein binding; lysophosphatidic acid receptor activity; signal transducer activity; G protein-coupled receptor activity;
Cellular component	integral component of plasma membrane; membrane; endocytic vesicle; integral component of membrane; plasma membrane; cell surface;
Biological process	activation of phospholipase C activity; signal transduction; positive regulation of cytosolic calcium ion concentration; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	9170
	53978
	ENSG00000064547
	ENSMUSG00000031861
	Q9HBW0
	Q9JL06; Q6P290
	NM_004720; NM_001395660
	NM_020028
	NP_004711
	NP_064412
	Wikidata
View/Edit Human	View/Edit Mouse

Lysophosphatidic acid receptor 2 also known as LPA₂ is a protein that in humans is encoded by the LPAR2 gene.^[5]^[6]^[7] LPA₂ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).^[8]

Function

This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca²⁺ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins.^[5]

Interactions

LPAR2 has been shown to interact with TRIP6.^[9]

Evolution

Paralogues

Source:^[10]^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000064547 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031861 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: LPAR2 Lysophosphatidic acid receptor 2".
^ An S, Bleu T, Hallmark OG, Goetzl EJ (April 1998). "Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid". J. Biol. Chem. 273 (14): 7906–10. doi:10.1074/jbc.273.14.7906. PMID 9525886.
^ An S, Bleu T, Zheng Y, Goetzl EJ (November 1998). "Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization". Mol. Pharmacol. 54 (5): 881–8. doi:10.1124/mol.54.5.881. PMID 9804623. S2CID 37327084.
^ Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.
^ Xu J, Lai Yun-Ju, Lin Weei-Chin, Lin Fang-Tsyr (March 2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor". J. Biol. Chem. 279 (11). United States: 10459–68. doi:10.1074/jbc.M311891200. ISSN 0021-9258. PMC 3904432. PMID 14688263.
^ "GeneCards®: The Human Gene Database".
^ "Ensembl Genome Browser".

External links

"Lysophospholipid Receptors: LPA₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-05.
Lysophospholipid+receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000064547 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031861 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: LPAR2 Lysophosphatidic acid receptor 2".

[pmid9525886-6] An S, Bleu T, Hallmark OG, Goetzl EJ (April 1998). "Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid". J. Biol. Chem. 273 (14): 7906–10. doi:10.1074/jbc.273.14.7906. PMID 9525886.

[pmid9804623-7] An S, Bleu T, Zheng Y, Goetzl EJ (November 1998). "Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization". Mol. Pharmacol. 54 (5): 881–8. doi:10.1124/mol.54.5.881. PMID 9804623. S2CID 37327084.

[Choi_2010-8] Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.

[pmid14688263-9] Xu J, Lai Yun-Ju, Lin Weei-Chin, Lin Fang-Tsyr (March 2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor". J. Biol. Chem. 279 (11). United States: 10459–68. doi:10.1074/jbc.M311891200. ISSN 0021-9258. PMC 3904432. PMID 14688263.

[10] "GeneCards®: The Human Gene Database".

[11] "Ensembl Genome Browser".

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LPAR2

LPAR2

LPAR2

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Hub overview

Root Wikipedia Article

LPAR2

Function

Interactions

Evolution

Paralogues

See also

References

Further reading

External links