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LPAR5
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| LPAR5 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | LPAR5, GPR92, GPR93, KPG_010, LPA5, lysophosphatidic acid receptor 5 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 606926; MGI: 2685918; HomoloGene: 10696; GeneCards: LPAR5; OMA:LPAR5 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Lysophosphatidic acid receptor 5 also known as LPA5 is a protein that in humans is encoded by the LPAR5 gene.[5][6][7][8][9] LPA5 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[10]
See also
[edit]References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000184574 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067714 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23". Nature Genetics. 26 (3): 345–348. November 2000. doi:10.1038/81664. PMID 11062477. S2CID 38870810.
- ^ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, et al. (September 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155.
- ^ Lee CW, Rivera R, Gardell S, Dubin AE, Chun J (August 2006). "GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5". The Journal of Biological Chemistry. 281 (33): 23589–23597. doi:10.1074/jbc.M603670200. PMID 16774927.
- ^ Kotarsky K, Boketoft A, Bristulf J, Nilsson NE, Norberg A, Hansson S, et al. (August 2006). "Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes". The Journal of Pharmacology and Experimental Therapeutics. 318 (2): 619–628. doi:10.1124/jpet.105.098848. PMID 16651401. S2CID 5989815.
- ^ "Entrez Gene: GPR92 G protein-coupled receptor 92".
- ^ Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, et al. (January 2010). "LPA receptors: subtypes and biological actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.
Further reading
[edit]- Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (June 2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. S2CID 7116392.
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