Lao Airlines Flight 301 was a scheduled domestic passenger flight from Vientiane to Pakse, Laos. On 16 October 2013, the ATR 72-600 aircraft operating the flight crashed into the Mekong River near Pakse, killing all 49 people on board. The accident was the first involving an ATR 72-600 and the deadliest ever to occur on Lao soil.

The investigation report concluded that the probable cause of the accident was the flight crew's failure to properly execute the published missed approach procedure following an aborted landing at Pakse airport.

The aircraft was operating a scheduled domestic passenger flight from Wattay International Airport, Vientiane to Pakse International Airport, Pakse, Laos. The flight departed from Vientiane at 14:45 local time (07:45 UTC) and crashed into the Mekong River at 15:55 local time (08:55 UTC) while approaching Pakse for the second time, less than 6 kilometres (3.7 mi; 3.2 nmi) from the airport. The aircraft had already gone around once due to poor weather and was in the downwind leg for another approach when it crashed into a riverbank and was deflected into the river. All five crew and 44 passengers on board were killed.

Marks on the ground indicated that the aircraft landed heavily on the ground before entering the Mekong. The weather was reported to be poor at the time of the accident due to the remnants of Typhoon Nari affecting southern Laos.

The fast-flowing, deep waters of the Mekong hampered the recovery of the victims and wreckage. To assist with the search, 50 divers from Thailand were brought in. Eighteen victims had been recovered as of 18 October. By 23 October 44 of the 49 victims had been recovered. Identification had been confirmed for 27 of them. Some of the victims were found 19 kilometres (12 mi; 10 nmi) downstream of the crash site.

The aircraft involved was an ATR 72-600 with serial number 1071 and registered as RDPL-34233. Lao Airlines had taken delivery of the aircraft on 29 March 2013, and until the point of impact, the aircraft had logged 758 Airframe hours. It was equipped with two Pratt & Whitney PW127M engines.

The victims were of eleven nationalities. Of the 44 passengers on board, 16 were Lao, as were four of the five crew. The remaining casualties consisted of seven French nationals, six Australians, five Thais, three South Koreans, three Vietnamese, and one each from China, Taiwan, Malaysia and the United States. At least two children, both from Australia, were among the dead. Early reports that a Canadian national was on board were incorrect, as it was later determined that the individual was a Vietnamese national.

In command was Cambodian Captain Yong Som (57), who had logged 5,600 flying hours, of which 3,200 on the ATR-72, and the first officer was Soulisack Houvanthong (22), who had logged around 400 hours of flying experience.