Laurel Run is a borough that is located in Luzerne County, Pennsylvania, United States. The population was 560 at the time of the 2020 census.

Laurel Run was incorporated as a borough in 1881. The borough is home to one of the oldest continuing motorsport events in Pennsylvania. Since 1906, the annual Giants Despair Hillclimb has challenged motorists to race uphill on a one-mile stretch of East Northampton Street.

In 1915, a mine fire started in the borough's Red Ash mine. The mine was excavated and, although the fire was declared extinguished in 1973, the fire is still burning.

Approximately 166 homes, two grocery stores, a church, a school, and a lumberyard were razed and relocated through a program administered by the Appalachian Regional Commission.

Laurel Run is located at 41°13′2″N 75°50′29″W / 41.21722°N 75.84139°W / 41.21722; -75.84139 (41.217222, -75.841456).

According to the United States Census Bureau, the borough has a total area of 5.2 square miles (13.4 km²), all land. The borough is sparsely populated. Most of Laurel Run consists of mountainous forests.

Laurel Run, a tributary of Mill Creek, flows through much of the borough.

At the time of the 2000 census, there were 723 people, 277 households, and 188 families living in the borough.