Lawrence is a city located in Essex County, Massachusetts, United States, on the Merrimack River. At the 2020 census, the city had a population of 89,143. Surrounding communities include Methuen to the north, Andover to the southwest, and North Andover to the east. Lawrence and Salem were the county seats of Essex County, until the state abolished county government in 1999. Lawrence is part of the Merrimack Valley.

Manufacturing products of the city include electronic equipment, textiles, footwear, paper products, computers, and foodstuffs. Lawrence was the residence of the poet Robert Frost for his early school years; his essays and poems were first published in the Lawrence High School newspaper. Lawrence is also the birthplace of composer and conductor Leonard Bernstein in 1918, and singer Robert Goulet in 1933.

Native Americans lived along the Merrimack River for thousands of years before European colonization of the Americas. Evidence of farming at Den Rock Park and arrowhead manufacturing on the site where the Wood Mill now sits have been discovered.

At the time of contact in the early 1600s, the Pennacook or Pentucket had a presence north of the Merrimack, while Massachusett, Naumkeag, and Agawam controlled territory south of the river. The territory which would later be aggregated into the city of Lawrence was purchased from Pennacooks Sagahew and Passaquo in 1642 for the English settlement of Haverhill, and from Massachusett sachem Cutshamekin in 1646 as a post-hoc payment for the lands surrounding the English settlement of Andover (modern-day North Andover center).

Europeans first settled the Haverhill area in 1640, colonists from Newbury following the Merrimack River in from the coast. The area that would become Lawrence was then part of Methuen and Andover. The first settlement within present-day city limits came in 1655 with the establishment of a blockhouse in Shawsheen Fields, now South Lawrence.

The future site of the city (formerly parts of Andover and Methuen), was purchased by a consortium of local industrialists. The Water Power Association members: Abbott Lawrence, Edmund Bartlett, Thomas Hopkinson of Lowell, John Nesmith and Daniel Saunders, had purchased control of Peter's Falls on the Merrimack River and hence controlled Bodwell's Falls the site of the present Great Stone Dam. The group allotted fifty thousand dollars to buy land along the river to develop. In 1844, the group petitioned the legislature to act as a corporation, known as the Essex Company, which incorporated on April 16, 1845. The first excavations for the Great Stone Dam to harness the Merrimack River's water power were done on August 1, 1845. The Essex Company would sell the water power to corporations such as the Arlington Mills, as well as organize the construction of mills and build to suit. Until 1847, when the state legislature recognized the community as a town, it was called interchangeably the "New City", "Essex" or "Merrimac". The post office, built in 1846, used the designation "Merrimac". The city was incorporated in 1853, and named for Abbott Lawrence.

Canals were dug on both the north and the south banks to provide power to the factories that would soon be built on its banks as both mill owners and workers from across the city and the world flocked to the city in droves; many were Irish laborers who had experience with similar building work. The work was dangerous: injuries and even death were common.

The Pemberton Mill collapse occurred on January 10, 1860, in Lawrence, Massachusetts. The five-story textile mill, built in 1853, was a major employer, particularly for Irish immigrants, many of whom were women and children. At the time of the collapse, around 600–800 workers were inside, though exact numbers vary. The official death toll was 88, with estimates of 116–145 deaths and hundreds injured, many permanently disabled. The disaster was one of the deadliest industrial accidents in U.S. history. Investigations pinned the collapse on substandard construction, specifically defective cast-iron columns that were too weak to support the mill’s weight. Poor oversight, cost-cutting by owners, and overloading the structure with heavy machinery exacerbated the issue. The mill was known to vibrate heavily during operation, a warning sign ignored. As immigrants flooded into the United States in the mid to late 19th century, the population of Lawrence abounded with skilled and unskilled workers from several countries. Protesting conditions, in 1912 they walked out of the mills. The action, sometimes celebrated as the Bread and Roses Strike, was one of the more important, widely reported, labor struggles in American history.