Artificial leather, also called synthetic leather, is a material intended to substitute for leather in upholstery, clothing, footwear, and other uses where a leather-like finish is desired but the actual material is cost prohibitive or unsuitable due to practical or ethical concerns. Artificial leather is known under many names, including leatherette, imitation leather, faux leather, vegan leather, PU leather (polyurethane), and pleather.

Artificial leathers are often used in clothing fabrics, furniture upholstery, water craft upholstery, and automotive interiors.

One of its primary advantages, especially in cars, is that it requires little maintenance in comparison to leather, and does not crack or fade easily, though the surface of some artificial leathers may rub and wear off with time. Artificial leather made from polyurethane is washable, but varieties made from polyvinyl chloride (PVC) are not easily cleaned.

Depending on the construction, the artificial leather may be porous and breathable, or may be impermeable and waterproof.

Porous artificial leather with a non-woven microfibre backing is a popular choice for clothing, and is comfortable to wear.

Many different methods for the manufacture of imitation leathers have been developed.

A current method is to use an embossed release paper known as casting paper as a form for the surface finish, often mimicking the texture of top-grain leather. This embossed release paper holds the final texture in negative. For the manufacture, the release paper is coated with several layers of plastic e.g. PVC or polyurethane, possibly including a surface finish, a colour layer, a foam layer, an adhesive, a fabric layer, a reverse finish. Depending on the specific process, these layers may be wet or partially cured at the time of integration. The artificial leather is cured, then the release paper is removed and possibly reused.

A fermentation method of making collagen, the main chemical in real leather, is under development.