Charles Leon Ruffin (February 11, 1912 – August 14, 1970) was an American catcher in Negro league baseball. He played for the Brooklyn Eagles, Newark Eagles, Pittsburgh Crawfords, and Philadelphia Stars between 1935 and 1946.

A native of Portsmouth, Virginia, Ruffin served in the US Navy during World War II. He died in Portsmouth in 1970 at age 58.