Lisa Edelstein (/ˈliːsə ˈɛdəlstiːn/ EDD-əl-steen; born May 21, 1966) is an American actress and artist. She is known for playing Dr. Lisa Cuddy on the Fox medical drama series House (2004–2011). Between 2014 and 2018, Edelstein starred as Abby McCarthy in the Bravo series Girlfriends' Guide to Divorce.

Edelstein was born in Boston, Massachusetts, to Bonnie and Alvin Edelstein, the youngest of three children in a Jewish family. Her father worked as a pediatrician at Chilton Memorial Hospital. She was raised in Wayne, New Jersey, and attended Wayne Valley High School, graduating in 1984.

At 16, Edelstein was a cheerleader for the New Jersey Generals. Edelstein participated in a protest against poor working conditions. She said she felt they were treated "like hookers" and helped organize a cheerleader walkout.

While living in New York, she became involved in the club scene (known there only as "Lisa E") with "celebutant" James St. James, who briefly refers to Edelstein in his 1999 book Disco Bloodbath. She caused enough of a stir in the community to be dubbed New York City's "Queen of the Night" by Maureen Dowd in a 1986 article of The New York Times entitled "Lisa In Wonderland."

In response to the growing AIDS crisis of the 1980s, Edelstein wrote, composed and starred in an original musical called Positive Me which she performed at La MaMa Experimental Theatre Club in New York City, receiving many accolades. She followed that with a short stint hosting MTV's Awake on the Wild Side in 1990, then began working in earnest as an actress. She got her SAG card appearing as a backstage make-up artist in Oliver Stone's Jim Morrison biography The Doors, and then landed a quick series of guest roles on several popular comedies, including Mad About You, Wings, The Larry Sanders Show, and Sports Night, where she played a sports reporter who claimed to be a former lover of Josh Charles' character whom he did not remember. Perhaps most famous from this time was her appearances on Seinfeld, where she played George Costanza's girlfriend in the episodes "The Mango" and "The Masseuse."

Bigger roles in TV dramas soon followed, among them the lesbian sister on ABC's Relativity (1996); a high-priced call girl turned Rob Lowe's date on The West Wing (1999); a transgender woman on Ally McBeal (2000); and Ben Covington's (Scott Speedman) girlfriend on Felicity (2001). She also continued to land guest-star spots on such shows as ER, Frasier, Just Shoot Me!, Without a Trace, and Judging Amy, as well as small parts in the films What Women Want, Keeping the Faith, As Good as It Gets, and Daddy Day Care.

From 2004 to 2011, Edelstein portrayed Lisa Cuddy, the Dean of Medicine at Princeton-Plainsboro Teaching Hospital and frequent adversary, friend, and eventual girlfriend of title character Gregory House (Hugh Laurie) on Fox's TV series House. Edelstein has often spoken fondly of her experiences on the show and fellow cast and crew, especially her friendship and strong working relationship with Laurie.

In May 2011, Edelstein announced that she would not return for the eighth and final season of House. Starting in June 2011, she joined the cast of The Good Wife, where she played lawyer Celeste Serrano. She guest-starred in Scandal in 2013, and later three episodes of the ABC series Castle.