Doctors is a British medical soap opera which began broadcasting on BBC One on 26 March 2000. Set in the fictional West Midlands town of Letherbridge, the soap follows the lives of the staff and patients of the Mill Health Centre, a fictional NHS doctor's surgery, as well as its sister surgery, the University of Letherbridge Campus Surgery. Head of St. Phils' gynaelogical department Ed Jordan (David Bark-Jones) was the first to debut in the year. He was followed by Liv Morgan (Livvi Parsons) in February, a foster child that Rob Hollins (Chris Walker) cares for. Joanna Bending then joined as doctor Michelle Walton in March, followed by temporary receptionist Paige Popplewell joining later that month. In June, Alex Avery joined as doctor Graham Elton. September then saw the arrival of Scarlett Kiernan's (Kia Pegg) housemate, Holly Lewin (Jessica Chisnall). Additionally, multiple other characters appear throughout the year. This was the final year that Doctors aired on television.

Ed Jordan, portrayed by David Bark-Jones, first appeared on 9 January 2024 and appeared until 29 January 2024. He was introduced as the head of the gynaecological department at St. Phils Hospital, as well as the former fiancé of established character Nina Bulsara (Wendi Peters). He is first seen in scenes where Nina arranges a meeting with the head of department to spark an investigation into the pain women are facing under his doctors' care. Nina "gets a blast-from-the-past" as she is unaware that Ed runs it. Ed shuts down Nina's claims of women's painful experiences and tries to say she is causing trouble due to him walking out on her without an explanation years prior, which infuriates Nina.

Ed invites Nina to dinner, which makes her hold off on sending a formal complaint. He tries to kiss her after dinner, to which she walks off. He soon arrives at the Mill Health Centre when she is seeing patients, trying to talk to her, which she also dismisses.

Liv Morgan, portrayed by Livvi Parsons, first appeared on 21 February 2025 and made her final appearance on 16 April 2025. She was introduced as a teenager that Rob Hollins (Chris Walker) begins fostering. She is initially wary of him due to him being a police sergeant and her family being criminals. Rob learns that she has been groomed by Stew McLaren (Harvey Zaffino), a man in his 20s. However, Liv becomes irritated with Rob asking questions about their relationship, giving him the "cold shoulder". Rob is disgusted when he learns that Liv and Stew are cousins.

Rob persuades Liv to attend a counselling session with Jimmi Clay (Adrian Lewis Morgan). However, she "makes it difficult" by keeping him guessing about what is troubling her. Liv eventually opens up by stating that she feels everyone leaves her eventually. Jimmi challenges her relationship with Stew, to her fury. She runs away and Rob finds her crying outside of Stew's flat, having found him with another woman. With his concerns growing over Liv's situation, Rob takes her fishing to attempt her opening up. The trip is successful, with Liv opening up to Rob and later making him breakfast. However, her "good mood does not last long" when Rob informs her that her stay as a foster child is soon to end, with Liv moving onto a permanent home.

Dr. Michelle Walton, portrayed by Joanna Bending, first appeared on 5 March 2024. Bending's casting was announced by her acting agency on 13 September 2023. Debuting six months later, her character was brought in as a temporary replacement for Emma Reid (Dido Miles), who is in Australia amidst Michelle's hiring. Her backstory involves knowing established characters Zara Carmichael (Elisabeth Dermot Walsh) from a conference in their youth and Luca McIntyre (Ross McLaren) from a medical course.

Michelle comes from Oldham and has remained in loose off-screen contact with Zara over the 20 years that they have been friends. In a video filmed for Doctors' social media platforms to introduce the character to fans, Bending revealed that she was friends with Walsh at drama school so felt that their characters being connected was "serendipitous". Bending opined that Michelle is a very kind doctor and someone who other characters will use as a "good shoulder to cry on". She also revealed that Michelle would be set to introduce an ex-partner to the Mill as a doctor to further help Zara.

This doctor was later revealed to be Graham Elton (Alex Avery), an ex of hers, as well as a former colleague. They rekindle their relationship briefly, but Graham calls it off after Michelle has to present a course on LGBTQIA+ awareness to him. She is then shown to be worried about his "concerning behaviour and micro-aggressions", particularly since he often feuds with Luca, her gay friend. Graham later asks if she would like to take over the Mill with him whilst Zara is bedbound from functional neurologic disorder (FND). She refuses and Graham uses his newfound power to terminate her contract. She is later part of a plan that sees Graham sacked and forced out of partnership. Michelle then becomes one of many to join as a partner following his exit.