The Interstate Highways in Alabama are the components of the Interstate Highway System in the U.S. state of Alabama. All numbered highways in Alabama are maintained by the Alabama Department of Transportation (ALDOT).

Currently, there are 11 routes and 1,130 miles (1,820 km) of Interstates in Alabama. The Interstate with the longest segment in Alabama is Interstate 65, covering 367.00 miles (590.63 km); the shortest is Interstate 359, covering 2.30 miles (3.70 km). There are six Interstate primary routes and five Interstate auxiliary routes serving the six largest cities in the state, and 22 of the 25 largest.