As defined by the German Federal Institute for Research on Building, Urban Affairs and Spatial Development, a Großstadt (large city) is a city with more than 100,000 inhabitants. As of today, 80 cities in Germany fulfill this criterion and are listed here. This list refers only to the population of individual municipalities within their defined limits, which does not include other municipalities or suburban areas within urban agglomerations or metropolitan areas.

The following table lists the 80 cities in Germany with a population of at least 100,000 each on 31 December 2021, as estimated by the Federal Statistical Office of Germany. A city is displayed in bold if it is a state or federal capital, and in italics if it is the most populous city in the state. The table below contains the following information:

Schwerin is the only state capital not listed.