The mayor of Agrigento is an elected politician who, along with the Agrigento's city council, is accountable for the strategic government of Agrigento in Sicily, Italy.

The current mayor is Francesco Miccichè, an independent politician, who took office on 21 October 2020.

According to the Italian Constitution, the mayor of Agrigento is member of the city council.

The mayor is elected by the population of Agrigento, who also elects the members of the city council, controlling the mayor's policy guidelines and is able to enforce his resignation by a motion of no confidence. The mayor is entitled to appoint and release the members of his government.

Since 1993 the mayor is elected directly by Agrigento's electorate: in all mayoral elections in Italy in cities with a population higher than 15,000 the voters express a direct choice for the mayor or an indirect choice voting for the party of the candidate's coalition. If no candidate receives at least 40% of votes, the top two candidates go to a second round after two weeks. The election of the City Council is based on a direct choice for the candidate with a preference vote: the candidate with the majority of the preferences is elected. The number of the seats for each party is determined proportionally.

From 1946 to 1993, the Mayor of Agrigento was elected by the City's Council.

Since 1993, under provisions of new local administration law, the Mayor of Agrigento is chosen by direct election, originally every four, then every five years.