This lists the singles that reached number one on the Spanish PROMUSICAE sales and airplay charts in 2018. Total sales correspond to the data sent by regular contributors to sales volumes and by digital distributors.
| Week | Issue date | Top Streaming, Downloads & Physical Sales | Most Airplay | ||||
|---|---|---|---|---|---|---|---|
| Artist(s) | Song | Ref. | Artist(s) | Song | Ref. | ||
| 1 | January 4 | Luis Fonsi featuring Demi Lovato | "Échame la Culpa" | [1] | Camila Cabello featuring Young Thug | "Havana" | [2] |
| 2 | January 11 | [3] | Ed Sheeran and Beyoncé | "Perfect" | [4] | ||
| 3 | January 18 | [5] | [6] | ||||
| 4 | January 25 | [7] | Camila Cabello featuring Young Thug | "Havana" | [8] | ||
| 5 | February 1 | [9] | Ed Sheeran and Beyoncé | "Perfect" | [10] | ||
| 6 | February 8 | Aitana and Ana Guerra | "Lo malo" | [11] | Morat and Juanes | "Besos en guerra" | [12] |
| 7 | February 15 | Daddy Yankee | "Dura" | [13] | Luis Fonsi featuring Demi Lovato | "Échame la Culpa" | [14] |
| 8 | February 22 | Bad Bunny | "Amorfoda" | [15] | [16] | ||
| 9 | March 1 | [17] | [18] | ||||
| 10 | March 8 | [19] | [20] | ||||
| 11 | March 15 | Nicky Jam and J Balvin | "X" | [21] | Ed Sheeran and Beyoncé | "Perfect" | [22] |
| 12 | March 22 | [23] | [24] | ||||
| 13 | March 29 | [25] | Charlie Puth | "How Long" | [26] | ||
| 14 | April 5 | [27] | Ed Sheeran and Beyoncé | "Perfect" | [28] | ||
| 15 | April 12 | Aitana and Ana Guerra | "Lo malo" | [29] | [30] | ||
| 16 | April 19 | [31] | [32] | ||||
| 17 | April 26 | [33] | Aitana and Ana Guerra | "Lo malo" | [34] | ||
| 18 | May 3 | [35] | Ed Sheeran and Beyoncé | "Perfect" | [36] | ||
| 19 | May 10 | Nio Garcia, Darell and Casper Magico | "Te Boté" | [37] | Selena Gomez and Marshmello | "Wolves" | [38] |
| 20 | May 17 | [39] | Álvaro Soler | "La Cintura" | [40] | ||
| 21 | May 24 | [41] | [42] | ||||
| 22 | May 31 | [43] | Aitana and Ana Guerra | "Lo malo" | [44] | ||
| 23 | June 7 | Cepeda | "Esta vez" | [45] | Selena Gomez and Marshmello | "Wolves" | [46] |
| 24 | June 14 | Becky G and Natti Natasha | "Sin Pijama" | [47] | Álvaro Soler | "La Cintura" | [48] |
| 25 | June 21 | [49] | [50] | ||||
| 26 | June 28 | [51] | [52] | ||||
| 27 | July 5 | [53] | [54] | ||||
| 28 | July 12 | [55] | Calvin Harris and Dua Lipa | "One Kiss" | [56] | ||
| 29 | July 19 | [57] | Álvaro Soler | "La Cintura" | [58] | ||
| 30 | July 26 | [59] | [60] | ||||
| 31 | August 2 | Aitana | "Teléfono" | [61] | Marshmello and Anne-Marie | "Friends" | [62] |
| 32 | August 9 | [63] | Álvaro Soler | "La Cintura" | [64] | ||
| 33 | August 16 | [65] | Calvin Harris and Dua Lipa | "One Kiss" | [66] | ||
| 34 | August 23 | [67] | Álvaro Soler | "La Cintura" | [68] | ||
| 35 | August 30 | [69] | Calvin Harris and Dua Lipa | "One Kiss" | [70] | ||
| 36 | September 6 | [71] | [72] | ||||
| 37 | September 13 | Ozuna and Manuel Turizo | "Vaina Loca" | [73] | Melendi with Alejandro Sanz and Arkano | "Déjala que baile" | [74] |
| 38 | September 20 | [75] | [76] | ||||
| 39 | September 27 | [77] | Calvin Harris and Dua Lipa | "One Kiss" | [78] | ||
| 40 | October 4 | 6ix9ine featuring Anuel AA | "Bebe" | [79] | Eleni Foureira | "Fuego" | [80] |
| 41 | October 11 | DJ Snake featuring Selena Gomez, Ozuna and Cardi B | "Taki Taki" | [81] | Blas Cantó | "Él no soy yo" | [82] |
| 42 | October 18 | Bad Bunny featuring Drake | "Mia" | [83] | Eleni Foureira | "Fuego" | [84] |
| 43 | October 25 | [85] | Maroon 5 | "Girls Like You" | [86] | ||
| 44 | November 1 | [87] | [88] | ||||
| 45 | November 8 | Rosalía | "Di mi nombre" | [89] | [90] | ||
| 46 | November 15 | [91] | [92] | ||||
| 47 | November 22 | Paulo Londra | "Adán y Eva" | [93] | [94] | ||
| 48 | November 29 | [95] | Clean Bandit featuring Demi Lovato | "Solo" | [96] | ||
| 49 | December 6 | Aitana | "Vas a quedarte" | [97] | Maroon 5 | "Girls Like You" | [98] |
| 50 | December 13 | Paulo Londra | "Adán y Eva" | [99] | Beret | "Lo siento" | [100] |
| 51 | December 20 | [101] | Maroon 5 | "Girls Like You" | [102] | ||
| 52 | December 27 | [103] | David Bisbal and Greeicy | "Perdón" | [104] | ||
