Little Barford is a hamlet and civil parish in the Borough of Bedford in Bedfordshire, England about 7 miles (11 km) northeast of the county town of Bedford.

The 2011 census combines other data for Little Barford with Wyboston, Chawston and Colesden civil parish but its population is separately shown as 44.

Little Barford Power Station is in the parish.

The manor of Barford was held by the de Leyham family from about 1194, and then passed by inheritance into the de la Dale family in about 1316: the de la Dales owned Barford for two centuries, after which it passed by inheritance to the Fettiplace family, and subsequently to the Brownes.

A deserted medieval settlement in fields near to St Deny's Church is visible as earthworks on historic aerial photographs.

The parish church is dedicated to Saint Denys. The church became redundant in 1972 and is now in the care of the Churches Conservation Trust.

A school was built in 1872. It became a council school in 1914 and closed in 1932, but reopened from 1939 to 1945. The building still stands.

The coal fired Little Barford Power Station was opened in 1939, closed in 1981 and demolished in 1989. A new gas fired plant was built in 1994–96.