Louhans (French pronunciation: [lu.ɑ̃]) is a commune in the Saône-et-Loire department in the region of Bourgogne-Franche-Comté in eastern France. Louhans is the capital of Bresse bourguignonne and a subprefecture of the department.

Louhans is centrally located on the plain of Bresse, a strongly agricultural region in the eastern part of the department of Saône-et-Loire. The Vallière forms part of the commune's southeastern border, then flows into the Solnan, which forms part of the commune's southern border. The Solnan flows into the Seille in the town. The Seille flows south-southwest through the western part of the commune and crosses the town.

The population data given in the table below for 1968 and refer to the commune of Louhans in its geography at the given dates. In 1973 Louhans absorbed the former communes of Châteaurenaud, Branges and Sornay. In 1979 Branges and Sornay were re-established as independent communes.

The town's church has a fine tower of the 15th century, of which the balustrade is carved so as to form the first words of the Ave Maria. There are also a hospital of the 17th century with a collection of ancient earthenware, a town hall of the 18th century and remains of ramparts of the 16th and 17th century.