MNT (gene)

MNT (Max-binding protein MNT) is a Max-binding protein that is encoded by the MNT gene

The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. Its delta signature is 44. This protein is a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA and recruiting Sin3 corepressor proteins through its N-terminal Sin3-interaction domain

MNT (gene) has been shown to interact with MLX, SIN3A and MAX.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.