The Mackay Region is a local government area located in North Queensland, Queensland, Australia. Established in 2008, it was preceded by three previous local government areas with modern histories extending back as far as 1869.

It has an estimated operating budget of A$118 million.

In the 2021 census, the Mackay Region had a population of 121,691 people.

Yuwibara (also known as Yuibera, Yuri, Juipera, Yuwiburra) is an Australian Aboriginal language spoken on Yuwibara country. It is closely related to the Biri languages/dialects. The Yuwibara language region includes the landscape within the local government boundaries of the Mackay Region.

Prior to 2008, the Mackay Region was an entire area of three previous and distinct local government areas:

The city had its beginning in the Mackay Municipality which was proclaimed on 22 September 1869 under the Municipal Institutions Act 1864. Its first mayor was David Dalrymple, and the council first met on 1 December 1869. It achieved a measure of autonomy in 1878 with the enactment of the Local Government Act. With the passage of the Local Authorities Act 1902, Mackay became a Town on 31 March 1903, and was ultimately proclaimed a City on 17 August 1918.

On 11 December 1879, the Pioneer Division came into being as one of Queensland's 74 divisions created under the Divisional Boards Act 1879 on 11 November 1879, chaired by John Ewen Davidson. On 31 March 1903, Pioneer became a Shire. Two areas split away from it over the next decade; the Shire of Sarina on 1 January 1912, and the Shire of Mirani on 4 September 1913.

On 21 November 1991, the Electoral and Administrative Review Commission, created two years earlier, produced its second report, and recommended that local government boundaries in the Mackay area be rationalised. The Local Government (Mackay and Pioneer) Regulation 1993 was gazetted on 17 December 1993, and on 30 March 1994, the two amalgamated into a larger City of Mackay, which first met on 8 April 1994.