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Malcolm Stevens
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Malcolm Francis Graham Stevens is an English chemist and Emeritus professor of the University of Nottingham, having previously worked at Aston University where he developed the cancer drug temozolomide.[1][2]
Key Information
Education and family
[edit]Stevens attended Bolton School, Lancashire, and then obtained a BSc and PhD at the University of Nottingham.[3]
He married Valerie Deans at Christ Church, Heaton, Bolton, in 1961.[4][5]
Career
[edit]Stevens took up a post of Reader in the Department of Pharmaceutical Sciences at Aston University in 1972, and was later appointed Professor. He was a member of the Cancer Research UK Experimental Cancer Chemotherapy group from 1980 to 2006, moving to the University of Nottingham in 1992.[2][6] Stevens's lab synthesised Temozolomide, which as of 2019, remains the only FDA-approved drug to treat the deadly brain tumor Glioblastoma multiforme. Temozolomide has had a substantial impact in the clinic: the 5-year survival with radiation alone is 4%, whilst with radiation plus temozolomide, it approaches 17%. The 10 year survival without temozolomide is <1% versus around 8% with temozolomide. Thus, long term survivorship with GBM is now possible (if not common), thanks to the work of Stevens and his group.[7][8]
Recognition
[edit]Stevens was appointed OBE in the 1999 New Year Honours "For services to the development of Cancer Drugs", being described as "Professor of Experimental Cancer Chemotherapy, University of Nottingham".[9] He was elected a Fellow of the Royal Society in 2009.[1]
References
[edit]- ^ a b "Malcolm Stevens". The Royal Society. Retrieved 5 September 2017.
- ^ a b "Malcolm Stevens". School of Pharmacy. University of Nottingham. Retrieved 5 September 2017.
- ^ "100 Inspiring Minds – Professor Malcolm Stevens OBE, FRS". Bolton School. Archived from the original on 6 September 2017. Retrieved 5 September 2017.
- ^ "Marriage index entry". FreeBMD. ONS. September 1961. Retrieved 6 September 2017.
- ^ "Marriage Indexes". lancashirebmd.org.uk. Retrieved 6 September 2017.
- ^ "Professor Malcolm Stevens OBE, FRS". 50 Aston Greats. Aston University. Retrieved 5 September 2017.
- ^ Weller, Michael; et al. (17 June 2019). "How we treat glioblastoma". ESMO Open. 4 (Suppl 2) e000520. doi:10.1136/esmoopen-2019-000520. PMC 6586206. PMID 31297242.
- ^ Stupp, Roger; et al. (10 March 2005). "Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma". New England Journal of Medicine. 352 (10): 987–996. doi:10.1056/NEJMoa043330. PMID 15758009.
- ^ "No. 55354". The London Gazette (Supplement). 31 December 1998. p. 13.
