Manizales (Spanish pronunciation: [maniˈsales]) is a city in central Colombia. It is the capital of the Department of Caldas, and lies near the Nevado del Ruiz volcano.

Currently, the city is the main center for the production of Colombian coffee and an important hub for higher educational institutions.

Manizales was founded on October 12, 1849. The city was founded by a group of twenty Antioquians (The Expedition of the 20), who came from Neira and Salamina.

Manizales is the capital city of one of the smallest Colombian departments. The city is described as having an "abrupt topography", and lies on the Colombian Central Mountain Range (part of the longest continental mountain range, the Andes), with a great deal of ridgelines and steep slopes, which, combined with the seismic instability of the area, has required architectural adaptations and public works to make the city safer. Even though Manizales has this very difficult topography, there are many coffee plantations in its fertile lands. The city is located in the northern part of the Colombian Coffee-Growers Axis ("Eje Cafetero"), near the volcano Nevado del Ruiz, which has an altitude of 5,321 meters (17,457.3 ft).

It is in the basin of the Chinchiná River and sub-basin of the Guacaica River. Its natural threats are earthquakes, mudslides, and volcanic eruptions.

Under the Köppen climate classification, Manizales is Cfb, a subtropical highland climate but ever moist. Lower elevations approach an equatorial climate (Af) as found in the plains. Despite being located in the tropics, the city seldom gets very hot, featuring spring-like temperatures throughout the year owing to its high altitude. There are only two seasons in the city: the wet and dry seasons that alternate throughout the year, with each lasting about three months. Monthly averages are quite uniform. Manizales receives about 1,500 millimetres (59 in) of precipitation a year, with October being wettest.

Its core economy has traditionally been the cultivation and production of coffee. This fomented the creation of new types of employment and several factories, some of which remain in the metropolitan area while others have reduced their operations or moved to other cities aggravating the unemployment problem. These companies manufacture products such as liquor, shoes, rubber, chocolate, banks, detergents and soaps, threshing and packaged coffee, software, and metallurgy, among others. In addition, there are institutions and companies involved in the coffee sector as the Departmental Committee of Coffee Growers of Caldas, Almacafé, Cenicafé, and a number of other industries involved in the process of coffee (threshers, cooperatives, exporters).

During the latter half of the twentieth century, many universities were founded in the city to the point that some studies regard Manizales as the second largest University city in the country. The universities are attended by students from various regions of the country such as Tolima, Risaralda, Valle, Quindio, Antioquia, Nariño and Huila, among others.