Mary Elizabeth Walton was most likely born sometime in the 1820's or 1830's. Details about her family and place of birth are not readily available. She would have experienced life in a rapidly changing America, marked by industrial growth and expanding cities, but also limited opportunities for women, especially in science and engineering. It's plausible she received some formal education, at least to the level generally deemed acceptable for women at the time, possibly at a local academy or through homeschooling. Her early experiences may have fostered a sense of observation and problem-solving, leading to her later inventive work.

This period likely involved further education (possibly through personal study or tutoring) and the development of practical skills. While formal scientific or engineering training was rare for women, she may have cultivated an interest in mechanics, chemistry, or engineering through available books, discussions with mechanically-inclined individuals, or by observing manufacturing processes. The emphasis during this period would have been on her development as a woman and her role within the domestic sphere.

Information regarding Mary Walton's marital status or whether she had children is unknown. During this time, a growing number of women started pursuing independent careers. It's likely she either entered into a marriage or remained single pursuing activities within her family or as an independent woman. This time also marks the period where her inventions started appearing.