Mastotermitidae is a family of termites with one sole living species, Mastotermes darwiniensis which is found only in northern Australia. The remaining genera of this family are only known from the fossil record.

Numerous fossil taxa have been described in the Mastotermitidae, as well as in the genus Mastotermes. The family seems to have had a worldwide distribution until just a few million years ago, when all but the ancestors of the giant northern termite became extinct for unknown reasons.

Genera included in the Mastotermitidae are: