After the pilot for "LAX 2194" fell through, Perry was cast as Chandler Bing in the NBC sitcom "Friends".

"Friends" became a huge success, making Perry an international celebrity. The cast earned $1 million per episode from 2002 onwards.

Perry received an Emmy nomination for Outstanding Lead Actor in a Comedy Series for his role in "Friends".

Perry appeared in films such as "Fools Rush In", "Almost Heroes", "Three to Tango", "The Whole Nine Yards", and its sequel "The Whole Ten Yards".