Mayo-Tsanaga is a department of Extreme-Nord Province in Cameroon. The department covers an area of 4,393 km² and at the 2005 Census had a total population of 699,971. The capital of the department is at Mokolo. It is located within the Mandara Mountains, on the border with Nigeria.

The department is divided administratively into 7 communes and in turn into villages.

10°44′24″N 13°48′10″E / 10.74000°N 13.80278°E / 10.74000; 13.80278