McDonnell & East Ltd Building is a heritage-listed former department store at 414 George Street, Brisbane, Queensland, Australia. It was designed by Thomas Ramsay Hall and built from 1912 to 1928 by Andrew Gillespie. It was added to the Queensland Heritage Register on 10 December 1997.

This three-storeyed brick department store building was erected in several stages between 1912 and 1963, for the Brisbane firm of McDonnell & East Ltd.

In 1886, Irishmen Frank McDonnell and Hubert East emigrated to Brisbane, where they were employed in the drapery trade. From 1889, McDonnell was closely connected with the movement for the early closing of shops. He entered Queensland Legislative Assembly in 1896 as the Labour member for Fortitude Valley, and largely due to his efforts, early closing was introduced in 1900.

In October 1901, the firm of McDonnell & East Ltd was established and, with the financial backing of businessman and publican Peter Murphy, owner of the Transcontinental Hotel, the firm purchased John Reid's drapery business, and the lease of the premises, at 402–408 George Street.

Within six years McDonnell & East Ltd was well established as a firm of importers, cash drapers, tailors, outfitters, dressmakers and milliners. About 1908, Jack McDonnell and Fraser and Harry East, sons of the founders, entered the firm.

In 1911, McDonnell & East Ltd acquired the adjoining George Street allotments to the corner of Tank Street, and in October 1911 Brisbane architect Thomas Ramsay Hall called tenders for a new brick building. The contract was let to Andrew Gillespie with a price of £10,734, which included electrical fittings, counter, fixtures and passenger lift. Construction began in January 1912, and the new building, advertised as the White Store, was occupied in April 1913. The company continued to lease the original building.

Following the success of the White Store, which doubled profits within a year, the company purchased a contiguous block in Tank Street, behind the new showrooms, in 1913. In mid-1914 TR Hall again called tenders for a store for McDonnell & East Ltd, and the contract was let to New Farm builder Mark Doggett, with a price of £1,310. This building was completed late in 1914, but it is not clear whether it remains as part of the present complex.

The business flourished, assisted by the re-location of the Brisbane Markets to Roma Street in 1915, and the proximity of the tram stops in George Street and the Roma Street railway station, which brought custom. McDonnell & East Ltd became a public company in 1920.