Me, Myself & Irene is a 2000 American slapstick black comedy film produced, co-written, and directed by the Farrelly brothers, and starring Jim Carrey and Renée Zellweger. The film is about a Rhode Island state trooper named Charlie (Carrey) who, after years of continuously suppressing his feelings, suffers a psychotic breakdown that results in a second personality, Hank, and must deal with his newfound condition while escorting a woman named Irene (Zellweger) who is being hunted by her mob-affiliated ex-boyfriend. Chris Cooper, Robert Forster, and Richard Jenkins also star.

This was Carrey's first role in a 20th Century Fox film, along with being the Farrelly brothers' second film with Carrey since Dumb and Dumber (1994). Filming was done from May 11 to July 29, 1999, in various locations in Rhode Island and Vermont.

Me, Myself & Irene was released on June 23, 2000, and was a box office success. It received mixed reviews from film critics.

Meek veteran Rhode Island state trooper Charlie Baileygates has been taken advantage of by those around him, including his wife Layla. Almost immediately after their wedding, she begins to cheat on Charlie with their wedding limo chauffeur, Shonté, a black dwarf with a genius-level IQ.

Despite his friends warning him of Layla's infidelity, Charlie denies it, even after she gives birth to biracial triplets, Jamal, Lee Harvey, and Shonté Jr., who also appear to be geniuses. A few years later, Layla leaves with Shonté, abandoning the children with Charlie, who raises them as his own. While they love and respect Charlie, the rest of the town continually abuses him. After years of such treatment, he develops a split personality named "Hank Evans" to deal with confrontations Charlie avoids: Emerging whenever Charlie is under extreme stress, Hank is an over-the-top, rude, and violent persona reminiscent of characters played by Clint Eastwood. A psychiatrist prescribes medication to keep Hank suppressed.

Believing Charlie needs a vacation, his commanding officer orders him to escort beautiful Irene Waters from Rhode Island to Massena, New York, where she reportedly committed a hit-and-run. Irene insists her mob-connected ex-boyfriend Dickie fabricated the accusation to keep her from revealing his illegal activities to the authorities.

In Massena, Charlie turns over Irene to two EPA agents. A hitman with a contract on Irene kills one of the agents. She and Charlie flee, hastily leaving his medication behind, which causes Hank to emerge frequently. Charlie is unjustly blamed for the murder. FBI agents begin pursuing him and Irene, as do Boshane and Gerke, two crooked police officers on Dickie's payroll. The chase becomes a media spectacle, alerting Charlie's sons to his predicament.

Charlie and Irene return to Rhode Island, bonding along the way. Although Irene is taken by Charlie's personality, Hank worries her, as his aggressive personality and overestimation of his own toughness often gets them into trouble. Along the way, they pick up "Whitey", a waiter with albinism who claims to have killed his entire family. While stopping at a motel, Hank convinces Irene to have sex with him by impersonating Charlie. When Charlie realizes what happened the next morning, he is incensed and begins fighting with Hank. They are almost ambushed by Boshane and Gerke, but Charlie's sons, having found them, steal a police helicopter and call in a false report, stating Charlie and Irene have been apprehended in the woods nearby.