Mekong Hotel (Thai: แม่โขงโฮเต็ล, romanized: Mæ̀ k̄hong ḥotĕl) is a 2012 Thai film directed by Apichatpong Weerasethakul. The film was screened in the Special Screenings section at the 2012 Cannes Film Festival.

Set in a quiet hotel overlooking the vast Mekong River in northeast Thailand that accommodates both living and undead guests. As its patrons hang around together on the veranda, listening music or playing guitar, a filmmaker rehearses a movie about the relationship between a vampiric woman and her daughter.

Mekong Hotel has a 67% approval rating on Rotten Tomatoes and holds a 57/100 on Metacritic.