Methestrol (INNTooltip International Nonproprietary Name; brand name Meprane) or methoestrol, also known as promethestrol or promethoestrol (BANTooltip British Approved Name) or as dimethylhexestrol, is a synthetic nonsteroidal estrogen of the stilbestrol group related to diethylstilbestrol which is no longer marketed.

A related drug is methestrol dipropionate (or promethestrol dipropionate) (brand name Meprane Dipropionate).