Metlakatla (/ˌmɛtləˈkætlə/; Tsimshian: Maxłaxaała or Tak'waan; Lingít: Tàakw.àani) is a census-designated place (CDP) on Annette Island in Prince of Wales-Hyder Census Area, Alaska, United States. At the 2010 census the population was 1,405; this had grown to 1,454 by the 2020 census.

Since the late 19th century, it has been the major settlement of the Metlakatla Indian Community of the federally recognized Annette Island Reserve, the only remaining reserve in Alaska. The Metlakatla voted to opt out of the Alaska Native Claims Settlement Act of the 1970s and retained rights to their land and waters. Membership in the community is primarily by lineage; it consists primarily of Tsimshian people and also includes those from other Alaskan Native tribes who wish to join the Metlakatla Indian Community as a bona fide member. Bona fide membership is granted upon approval of the Metlakatla Tribal Council and Executives.

Metlakatla comes from Maxłaxaała, a Tsimshian word meaning "saltwater passage where the wind dies down." Metlakatla was named after another village of the same name ("Old Metlakatla") in British Columbia, which is on Metlakatla Pass, near Prince Rupert. In a more ancient time, it was a Tlingit hunting ground known as Taquan, or Tàakw.àani. The Tsimshian were granted permission to occupy the land by Chief Johnson of the Tlingit tribe.

In 1886, William Duncan, an English tannery employee and lay member of the Church Missionary Society, had a doctrinal dispute with the Church authorities in Metlakatla, B.C. He and a devoted group of Tsimshian followers decided to leave Metlakatla. Duncan went to Washington, D.C., in the United States and asked the U.S. government to give his group land in Alaska. The U.S. under President Cleveland gave them Annette Island after a Tsimshian search committee in seagoing canoes discovered its calm bay, accessible beaches, nearby waterfall, and abundant fish.

In 1887, the group arrived on the island and built a settlement in the Port Chester area. They laid out the town in a European-style grid pattern. It contained a church, a school, a cannery, and a sawmill. They named the town New Metlakatla, after the town they had left behind, but later dropped the "New." In 1888, William Duncan returned to Washington and lobbied the U.S. Congress for an Indian reserve on Annette Island. Although the reservation system had not been used in Alaska, Congress granted his request in 1891. Duncan remained at Metlakatla until his death in 1918.

During World War II, the United States made a treaty with the Metlakatla Indian Community to permit construction and operation of a military airbase on Annette Island. In exchange, the US promised to build a road connecting the ocean-side city to Alaska's Inside Passage (in order to allow year-round ferry service to Ketchikan). The airfield on Annette Island was garrisoned by Canadians during the war. This airfield became "the first Canadian force ever based in U.S. territory to directly assist in American defense."

After the war, the property was adapted as a United States Coast Guard search and rescue base. This airfield served the area commercially until the 1970s, when the new Ketchikan Airport was built at Gravina Island in the Inside Passage.

Annette Islands Reserve, including surrounding islands, today is the only Indian Reserve in Alaska. In the 1970s, the Metlakatla did not accept the Alaska Native Claims Settlement Act and thus kept the Reserve Status, and maintained sovereign immunity. "Annette Islands Reserve consists of 132,000 acres of land and water base. Metlakatla Indian Community has exclusive commercial and subsistence fishing rights to the islands’ waterways extending from 3,000 feet at mean low tide."