Midwest Cascade, also known as West Cascade, is an affluent predominantly African-American neighborhood in southwest Atlanta at the city's far west edge. Together with the tiny neighborhood of Regency Trace, it forms NPU-Q, the city's fastest growing Neighborhood Planning Unit (NPU) from 2000 to 2010.

The neighborhood is 602.1 acres (2.437 km²) large and bounded by the City of South Fulton on all sides, except for the City of Atlanta's NPU-P, bordering the Ashley Courts and Niskey Lake neighborhoods on the southeast. It includes the following named subdivisions:

Midwest Cascade is located south of Cascade Road, along Regency Center Drive.

The Atlanta City Council voted to annex Midwest Cascade to the City of Atlanta on September 29, 2006.

NPU-Q went from 1,024 residents in 2000 to 1,770 in 2010, an increase of 72.9%.

The NPU is 96.5% Black (2010 census), the highest proportion of any NPU in the city. Small minorities include Whites (1.4%) and Hispanics (1.4%).

As of December 15, 2023, Midwest Cascade is home to the new West Cascade Park located on Danforth Road. The neighborhood's NPU was the last one to officially receive a park.

Atlanta Public Schools serves Midwest Cascade.